Initiation of single-inhaler COPD triple therapy improved adherence compared to multiple inhalers

March 30, 2022

2 minute read


Disclosures: The study was funded by GlaxoSmithKline. Mannino claims to have been an employee of GlaxoSmithKline. Please see the study for relevant financial information from all other authors.


We have not been able to process your request. Please try again later. If you continue to have this problem, please contact [email protected]

According to a real-world study, COPD patients who started single-inhaler triple therapy had improved inhaler adherence and persistence compared to multiple-inhaler triple therapy users.

Researchers conducted a retrospective analysis of 2,782 COPD patients (mean age, 60.6 years; 54.5% female) in the IQVIA PharMetrics Plus claims database who started triple therapy with fluticasone furoate , umeclidinium and vilanterol (Trelegy Ellipta; GlaxoSmithKline and Innoviva) from September 2017 to June 2019. The researchers also examined data from 7,160 patients using multiple inhaler triple therapy (mean age, 60.4 years 52.1% women). All patients were at least 40 years old and had at least 12 months of continuous insurance coverage before initiation and at least 6 months of coverage after initiation.



Source: Adobe Stock.

At 6 months, patients who started single-inhaler triple therapy had higher inhaler adherence, with a mean proportion of days covered of 0.66 versus 0.48 (P

The researchers also analyzed 1,337 single-inhaler triple therapy users and 3,442 multiple-inhaler triple therapy users with 12 months or more of follow-up data in a subgroup analysis. In the subgroup analysis, single inhaler triple therapy users had a higher proportion of days covered compared to multiple inhaler triple therapy users (0.6 versus 0.4; P

Compared to multiple inhaler triple therapy, single inhaler triple therapy users were also twice as likely to adhere to their inhaler therapy (22.3% vs. 46.5%; RR=2.08; 95% CI %, 1.85-2.3; P P P P

In the subgroup analysis, after 12 months, more patients who initiated single-inhaler triple therapy persisted in their treatment compared to patients using multiple-inhaler triple therapy (35.7% vs. 13.9%; HR = 1.91, 95% CI, 1.81-2.01; P

“Thus, the improvements in adherence and persistence observed in this study for patients initiating a single inhaler of fluticasone furoate/umeclidinium/vilanterol are very promising. Further studies are needed to understand how the observed improvements in “adherence and persistence with fluticasone furoate/umeclidinium/vilanterol translates into clinical and economic benefits”, David Mannino, MD, respiratory medicine expert at GlaxoSmithKline, and his colleagues wrote in respiratory medicine.